The research personnel from the Arts/Gao/Mann labs are located on the 2nd floor of the SDRI building but are moving to new state-of-the-art CL2+/CL3 facilities with Western HIV Investigator Group (WHIG) in 2016. The 6000 sqft ImPaKT biochemistry labs and the 4000 sqft ImPaKT CL2+/CL3 facilities will house projects on: HIV vaccine development, HIV virulence and evolution, HIV Cure, and drug resistance.
A core of 5 to 8 Ugandan scientists work in the CFAR Uganda molecular virology labs at the JCRC, directed by Dr. Immaculate Nankya. This lab was established by Dr. Arts in 1998 with the primary mission to understand HIV pathogenesis and to provide advanced clinical virology assays. As a WHO Regional Lab, the CFAR Uganda labs have performed over 5000 HIV-1 drug resistance tests for patients in East Africa.
With Dr. Miguel Quinones-Mateu we have been at the forefront of new vaccine approaches and new tests for HIV-1 clinical care. The lab has patented new cloning strategies for viruses, new multiplex methods for SNP detection, and new pipelines for Next Generation Sequencing. The Arts/Gao/Mann lab is also a participant of various international vaccine studies, EAVI2020 and collaborator of the first HIV vaccine trial in Canada.
Prof. Robin Shattock, Imperial College, UK and EAVI2020: HIV-1 transmission, vaccine, and CURE studies
Drs. Sarah Fidler and Caroline Foster, Imperial College and St. Mary’s Hospital, UK: HIV-1 CURE studies
Dr. Immaculate Nankya, Joint Clinical Research Centre, Uganda: HIV-1 pathogenesis and drug resistance
Dr. Miguel Quinones-Mateu, Case Western Reserve University (CWRU) and UHTL, USA: Assay development and drug resistance
Dr. Jeff Bailey, University of Massachusetts, USA: Bioinformatics and HIV-1 evolution
Dr. Chuanwu Zhu, The Fifth Peoples Hospital of Suzhou, China: HIV-1 treatment outcomes and drug resistance
Dr. David McDonald, CWRU, USA: Restriction factors and HIV-1 pathogenesis
Dr. Robert Salata, CWRU, USA: HIV-1 clinical cohorts in Uganda
Dr. Jonathan Karn, CWRU, USA and Dr. Gabriele Varani, University of Washington, USA: HIV-1 RNA regulation and peptidomimetic inhibitors
Dr. James Mullins, University of Washington, USA: HIV-1 immune escape
The Arts laboratory was founded in 1997 by Dr. Eric J. Arts at Case Western Reserve University in Cleveland, Ohio and then established a satellite laboratory at the Joint Clinical Research Centre in Kampala, Uganda. In 2014, we moved to Western University in London, Ontario from CWRU with strong research team and established a new home in the Department of Microbiology and Immunology at the Schulich School of Medicine and Dentistry. Over the past 20 years, we were honoured to have over 100 graduate students, post-doctoral fellows, clinical fellows, undergraduate students, visiting scientists and research assistants have worked with us on research projects related to HIV-1 pathogenesis, evolution, drug resistance, and molecular biology. Three faculty with strong collaborative ties and sharing common lab infrastructure. Arts/Gao/Mann Laboratory - committed to having fun, to developing new technologies, to being geeky scientists, and to finding a cure and vaccine for HIV-1